I want to know the Capabilities and services of University of Dundee Drug Discovery Unit so can you please tell me?

The University of Dundee Drug Discovery Unit is a fully operational, fully integrated drug discovery group working across multiple disease areas.

They collaborate with partners to translate world-class biology research into novel drug targets and candidate drugs to address unmet medical need across our two areas of activity, Diseases of the Developing World and Innovative Targets Portfolio.

Capabilities-

Their Integrated Infrastructure

The DDU is housed within purpose-built facilities at the University of Dundee and has all the expertise required for early-stage drug discovery and development.

Translational Science

Drug Metabolism and Pharmacokinetics

Integrated DMPK group
Supports hit and lead optimisation programmes
Industry standard in vitro and in vivo assays
State-of-the-art UPLC-MS/MS


Hit Discovery

Comprehensive range of liquid handling and detector technologies, including nanolitre acoustic dispensing
Protein and cell-based screening
High-content imaging and analysis
Fragment-based screenings: SPR, NMR and Octet RED284
Industry standard data management - ActivityBase, Dotmatics

Medicinal Chemistry

Hit validation to lead optimisation
Parallel chemistry
Mass directed auto-prep HPLC purification
Structural Biology & Biophysical Techniques
State-of-the-art protein crystallography infrastructure
SPR: hit validation and determining enzyme kinetics

Bioinformatics

Statistics, computational science, databases, algorithms
Management and analysis of biological data
Mapping, analysing and aligning DNA and protein sequences
Building 3D models of protein structures

Computational Drug Design

Druggability assessment of molecular targets
Library selection
Virtual screening
Analysis of hits from screening
Pharmacophore searching
Compound design using protein structures
In silico ADMET optimisation

Commercial services

At the DDU their business model is flexible. Their services are available via research collaboration, partnership or on more commercial terms. C

Fragment Screening
Small Molecule Screening
Medicinal Chemistry & Computational Chemistry
DMPK
Protein Production
NMR

Contact-

Drug Discovery Unit
School of Life Sciences
University of Dundee
Dow Street
Dundee DD1 5EH

Email: ContactDDU@Dundee.ac.uk