Research at NIPER-Hyderabad is conducted in all the departments. NIPER-Hyderabad has been actively pursuing the following research areas which are:

Drug Discovery & Development
• Focus Areas: Cancer, diabetes, inflammation, infectious diseases & rare diseases
1. Medicinal chemistry ; Molecular modeling; IP evaluation
2. In vitro / in vivo biology
3. Process chemistry ; Formulation development
4. Regulatory toxicology
Product Development
• Focus areas: Development of novel formulations, efficient & cleaner processes and development of appropriate analytical methods
1. Formulation development ; IP evaluation
2. Process chemistry ; Scale up technologies
3. Pharmaceutical analysis
4. Toxicology studies

Medicinal Chemistry

This department is working in multi-disciplinary research programmes including organic synthesis, medicinal, combinatorial and green chemistry including chemical biology. The main objective of the department is to design and synthesis of new chemical entities for anti-cancer, anti-inflammatory, anti-depressant, anti-tubercular and anti-microbial activity in the drug discovery programme.

The targets are selected based on the structural information obtained from ligand-protein crystallographic structures, molecular modeling, novel molecular architecture, important biological activity and interesting mechanism of action. Next, a number of newly synthesized molecules could be tested their biological profile by complete in vitro studies on selected cell lines particularly based on the biological targets with complete mechanism of action.
The department is engaged in the following areas of research

• To discover and develop New Chemical Entities (NCEs) to cure cancer, inflammation, tuberculosis and bacterial infection.
• The application of Computational Chemistry for the design of new molecules of medicinal significance.
• Synthesis and biological evaluation of NCEs related to inhibition of various Tyrosine Protein Kinases (kinase-privileged scaffold).
• ). (PPAR-Molecules acting on topoisomerase enzyme and peroxisome proliferator-activated receptor-
• Acting on Microtubules and Kinesin Spindle Enzyme.
• NCEs causing the induction of Apoptosis.
• Discovery of novel modulators of human HDAC2 using computational approach.
• Development of new DNA interactive compounds (groove binders and intercalators) as anticancer agents.
• Combinatorial synthesis.
• Asymmetric synthesis of natural products of pharmacological importance.
• Asymmetric synthesis of chiral bioactive molecules.
• Development of new efficient synthetic methodologies for biologically active scaffolds.
• Development of green synthetic methodologies and their applications in the synthesis of bioactive molecules.
• Development of efficient homogenous/heterogeneous transition-metal catalysts and their application in various synthetic strategies.
• Online ESI-MS mechanistic studies to study the reaction mechanism and their reactive intermediates.
• One-pot syntheses of complex molecules from simple starting materials.
• Microwave-assisted synthesis.
• Computer Aided Drug Design (CADD): Target-based drug design, Pharmacophore modelling, Quantum Mechanical modelling, Homology modelling, Molecular simulations, etc.