Department of Biotechnology of Kurukshetra Univesity, Kurukshetra is aimed at high academic standards in teaching and research. The department has basic infrastructure to nourish M.Sc. students and for pursuing research in diverse fields of biotechnology like microbial, plants and animal biotechnology with the help of collaborating institutes having specialized facilities.

The curriculum for M.Sc. Biotechnology Program offered by Kurukshetra Univesity, Kurukshetra is as follows:

Semester – 1
Paper BT-101 Biomolecules

Unit-I
Water : Structure, hydrogen bonding, as a biological solvent, ionization and fitness of
the aqueous environment for living organisms; pH; Buffers; Henderson-Hasselbalch
equation; Physiological buffers.
Carbohydrates : Structure, occurrence and biological importance of important
monosaccharides, oligosaccharides and polysaccharides; Ring structures and
anomeric forms; mutarotation; sugar derivatives; reactions of monosaccharides;
Glycosaminoglycans; Heteropolysaccharides of bacterial and algal cell walls;
Proteoglycans; Glycoproteins; Lectins.

Unit-II
Amino acids and Proteins : Common structural features, classification by R group,
Zwitter ion structures, acid-base properties and titration curves of amino acids;
Essential amino acids; Separation of amino acids; Peptides including biologically
active peptides; Classification and different structural levels (Primary, secondary,
tertiary & quaternary) of proteins; Ramachandran plot; Determination of amino acid
composition of proteins; Characteristic amino acid composition of proteins;
Determination of amino acid sequences of proteins; Effect of amino acid sequence on
the function of a protein and stability of α-helix; Protein folding and role of
chaperons in protein folding; Chemical synthesis of polypeptides.

Unit-III
Lipids : Classification, structures, nomenclature and properties of fatty acids;
Essential fatty acids; Acylglycerols; Characterization of fats-Saponification value,
iodine number, rancidity, acid value,Reichert-Meissel number; Structures and
properties of different types of phospholipids and sphingolipids (sphingomyelins,
cerebrosides & gangliosides); Structure and functions of prostaglandins,
Prostacyclins, Thromboxanes, and Leukotrienes; Terpenes of biological significance;
Sterols and bile acids.

Unit-IV
Nucleic Acids : Structure and properties of purines and pyrimidine bases;
Nucleosides and Nucleotides; Biologically important nucleotides; Nucleic acids as the
genetic material – experimental evidences; Chargaff’s rules; The covalent backbone
of nucleic acids; Double helical model of DNA structure; Structural polymorphism of
DNA (A,B and Z-DNA) and RNA; Denaturation & annealing of DNA; Biological
functions of nucleotides; Chemical synthesis of oligonucleotides.

Recommended Books :
1. Lehninger: Principles of Biochemistry, 4th edition, by David L. Nelson and
M.M. Cox (2005) Maxmillan/Worth publishers/W.H. Freeman & Company
2. Biochemistry (2004) by J.David Rawn, Panima Publishing Corporation, New
Delhi
3. Biochemistry, 2nd edition, by R.H. Garrett and C.M. Grisham (1999). Saunders
College Publishing, N.Y. Sons, NY.
4. Biochemistry, 4th edition, by L.Stryer (1995). W.H. Freeman & Co., N.Y.
5. Fundamentals of Biochemistry, 2nd ed., by Donald Voet, Judith G.Voet and
Charlotte W. Pratt (2006), John Wiley & Sons, INC
6. Biochemistry: The chemical reactions of living cells, 2nd edition, by David
E.Metzler (2001), Harcourt Academic Press.
7. Principles of Peptide synthesis (1984), Miklos, Bodansky, Springer-Verlag
Berlin, Heidelberg

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