Propylthiouracil (Rx) PropylThyracil, PTU is Antithyroid Agents which is used for many diseases.

Hyperthyroidism

300-450 mg/day PO divided q8hr initially (may require up to 600-900 mg/day)

Maintenance: 100-150 mg/day divided q8hr

Thyrotoxic Crisis (Unlabeled)

Initial 200-300 mg PO q4-6hr initially on Day 1 (may require 800-1200 mg/day), then reduce gradually; some practitioners propose an initial dose of 600-1000 mg with gradual dose reduction after initial response

Maintenance: 100-150 mg/day PO divided q8-12hr

Graves Disease

50-150 mg PO q8hr initially

Maintenance: 50 mg PO q8-12hr for up to 12-18 months; then taper and discotinue if euthyroidism restored (TSH) is normal

Renal Impairment
Dose adjustment not necessary

Other Indications & Uses
Off-label: alcoholic liver disease

Adverse Effects

Agranulocytosis

Aplastic anemia

Dermatologic reactions

Hepatitis

Polyarthritis

Drowsiness

Fever