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June 16th, 2016, 11:09 AM
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Join Date: Mar 2012
Re: NIPER Exam Syllabus

Hello, here I m providing you the details of the syllabus of NIPER JEE exam as under:

Specialization subjects:
Medicinal chemistry and Bulk Drugs (Pharmaceutical Technology)

IUPAC nomenclature, R and S nomenclature, E and Z isomerism, atropiisomerism, Conformations

Hybridization, aromaticity, Huckel’s rule reaction mechanisms- Electrophilic, Nucleophilic, SN1, SN2, SNi, Elimination E1 E2 etc.

Imine-enamine Tautomerism, keto-enol tautomerism, pericyclic reactions, racemic mixture, resolution methods.

Amino acids proteins, various methods for amino acid detection, Ninhydrin test, peptide sequencing, structures of amino acids, essential and nonessential amino acids,

Introduction to thermal methods of analysis like, TGA, DSC, DTA etc.

Carbohydrates classification, osazone test, mutarotation, etc,

Various Heterocycles, Heterocycle synthesis, reactions.

Introduction to Redox reactions.

Spectroscopy: (basics specially): Very very IMP topic. NMR, and C-NMR ranges from Morrison & Boyd or Pavia Mass -Basic concepts about various peaks M+1, molecular ion, base peak etc. (Silverstein) IR - Frequencies of various groups specially carbonyls. UV
Chromatography: Details of every chromatographic method.

Reaction kinetics, first second third and pseudo first order reactions, radio labeling for determination of mechanism.

Common condensation reactions like Aldol, Claisen Perkin, Dickmann, Darzen etc.

Other reactions like Cannizarro’s reaction, Prins reaction, especially reactions of carbonyl compounds.

Natural Products:
In natural products more stress should be given on phytochemistry part rather than biological aspects.

Methods of extraction, isolation and characterization of natural products. Various separation techniques used for isolation of natural products.

Biosynthetic pathways.

Primary metabolites, their examples.

Secondary metabolites, various classes of secondary metabolites (e.g. Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, anthocyanidines etc.). Here most imp. Part is chemistry of these classes.

Important therapeutic classes: antidiabetics, hepatoprotectives, immmunomodulators, neutraceuticals, natural products for gynecological disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc.

Dietary antioxidants, Marine natural products, Plant growth regulators.

Spectroscopy: Basic concepts of UV, NMR, IR and Mass spectroscopy. Give more stress on IR and NMR.

Stereochemistry: Basic concepts.

Fischer, sawhorse and newmon projection formulaes.

Biological sources of important classes of natural products.

Standardization of natural products.

What is difference between natural products and pharmacognosy?

Practice of Pharmacy:
The best part for the preparation for this best reference for this would be Remington’s Pharmaceutical Sciences. This branch is quite new here, so till dates students of branch used to do case study of prescriptions in Fortis hospital, PGI Chandigarh and govt. college chd... This is much like pharmacology and drug-drug interactions and different interactions are emphasized. Diabetes
Pharmacoinformatics:
Terminologies related with new emerging informatics e.g. proteomics, genomics, QSAR (2D, 3D, regression, correlation).

Pharmaceutical analysis:
Stability testing of pharmaceuticals, various stability tests, kinetic studies, shelf life determination, thermal stability, formulation stability.
Various analytical techniques
Tests: physical and chemical tests, limit tests, microbiological tests, biological tests, disintegration and dissolution tests.
Spectroscopic methods; UV, NMR, IR, MS, FT-IR, FT-NMR, ATR (Attenuated Total Reflectance), FT-Raman- basics and applications.
Thermal techniques: DSC, DTA, TGA, etc.
Particle sizing: law of diffraction.
Electrophoresis: capillary electrophoresis.
Chromatography- detailed.
QA and QC: GLP, TQM, ISO system.
Preformulation, cyclodextrin inclusion compounds
Solubility: pH, pka, surfactant HLB values, Rheology.
Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity, surface area flow properties.
Dosage forms, Stages of dosage form development
Osmolality, osmolarity, osmotic pressure, conductivity, Preservatives, Media for bioassay.


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