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  #1  
June 11th, 2016, 02:39 PM
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NIPER Important Notes

Hello sir I am here as I want to get the Important Notes related to NIPER JEE exam as I have to start my preparation so will you please provide me the Notes???
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  #2  
June 11th, 2016, 04:25 PM
Super Moderator
 
Join Date: Mar 2012
Re: NIPER Important Notes

As you want Important Notes related to NIPER JEE exam but the notes are not available so below I am providing you syllabus of this Exam

Medicinal chemistry

-Medicinal chemistry and Bulk Drugs (Pharmaceutical Technology)
-IUPAC nomenclature, R and S nomenclature, E and Z isomerism, atropiisomerism, Conformations
-Hybridization, aromaticity, Huckel’s rule reaction mechanisms- Electrophilic, Nucleophilic, SN1, SN2, SNi, Elimination E1 E2 etc.
-Ester hydrolysis, Aac1 Aac2……all eight mechanisms (Jerry march) Markovnikoves rule, Bredts rule, Stereoselectivity, stereospecificity, regioselectivity, chemoselectivity, chirality, stereochemistry, conformations, rearrangements, acids and bases.
-Imine-enamine Tautomerism, keto-enol tautomerism, pericyclic reactions, racemic mixture, resolution methods.
-Amino acids proteins, various methods for amino acid detection, Ninhydrin test, peptide sequencing, structures of amino acids, essential and nonessential amino acids,
-Introduction to thermal methods of analysis like, TGA, DSC, DTA etc.
-Carbohydrates classification, osazone test, mutarotation, etc,
-Various Heterocycles, Heterocycle synthesis, reactions.
-Introduction to Redox reactions.
-Spectroscopy: (basics specially): Very very IMP topic. NMR, and C-NMR ranges from Morrison & Boyd or Pavia Mass -Basic concepts about various peaks M+1, molecular ion, base peak etc. (Silverstein) IR - Frequencies of various groups specially carbonyls. UV
-Chromatography: Details of every chromatographic method.
-Reaction kinetics, first second third and pseudo first order reactions, radio labeling for determination of mechanism.
-Common condensation reactions like Aldol, Claisen Perkin, Dickmann, Darzen etc.
-Other reactions like Cannizarro’s reaction, Prins reaction, especially reactions of carbonyl compounds.

Natural Products:

-In natural products more stress should be given on phytochemistry part rather than biological aspects.
-Methods of extraction, isolation and characterization of natural products. Various separation techniques used for isolation of natural products.
-Biosynthetic pathways.
-Primary metabolites, their examples.
-Secondary metabolites, various classes of secondary metabolites (e.g. Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, anthocyanidines etc.). Here most imp. Part is chemistry of these classes.
-Important therapeutic classes: antidiabetics, hepatoprotectives, immmunomodulators, neutraceuticals, natural products for gynecological disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc.
-Dietary antioxidants, Marine natural products, Plant growth regulators.
-Spectroscopy: Basic concepts of UV, NMR, IR and Mass spectroscopy. Give more stress on IR and NMR.
-Stereochemistry: Basic concepts.
-Fischer, sawhorse and newmon projection formulaes.
-Biological sources of important classes of natural products. (Selected ones only)
-Standardization of natural products.
-What is difference between natural products and pharmacognosy?


Pharmacology and toxicology:

-Pharmacokinetics, pharmacodynamics, pharmacological effect, desired, undesired, toxic, adverse effects.
-Bioavailability, bioequivalence, various factors of ADME. (From Bramhankar)
-Drug metabolism: various pathways and other details.
-Drug interactions, agonist, antagonist, partial agonist, protein binding, drug distribution, distribution volume, excretion pathways etc.
-Pharmacological screening: general principles, various screening models, screening methodologies (in vitro and in vivo tests).
-Mechanism of drug action, drug-receptor interaction.
-Various adrenergic, cholinergic and other receptors
-Detailed study of CNS pharmacology
-Study of basis of threshold areas of work in NIPER in pharmacology dept. mentioned in brochure.
-Diseases: study of the pharmacology of the diseases and drugs used with mode of action especially of diabetes, malaria, leishmaniasis, TB, hypertension, myocardial ischemia, inflammation, and immunomodualtion.
-Chemotherapy and pathophysiology- knowledge of antibiotics, their mode of action and the microorganisms responsible for various common diseases.
-Bioassay methods, various requirements. Brief knowledge of the statistical tests.


Pharmaceutics and formulation (Pharmaceuticl Technology)

-Drug delivery systems (DDS): NDDS models, osmotic pumps, various release patterns eg. Controlled release, delayed release. Sustained release etc., order of release. Oral controlled DDS, factors affecting controlled release.
-Carriers in DDS: polymers and their classification, types, carbohydrates, surfactants, proteins, lipids, prodrugs etc.
-Transdermal drug delivery systems (TDDS): principles, absorption enhancers, evaluation of TDDS.
-Parenterals: requirements, advantages, disadvantages, release pattern, route of drug delivery.
-Drug targeting: microspheres, nano particles, liposomes, monoclonal antibodies, etc.
-Preformulation detailed.
-Complexation, solubilization, polymerization, viscosity measurements.
-Dosage form development- stages, implications of dosage form.
-Additives of formulation, types, examples, advantages, disadvantages, drug excipient interaction, incompatibility, various types of incompatibilities.
-Dosage forms: solid (tablets, capsules, pills etc), liquid (emulsion, suspension etc), sterile (injectables), aerosols. Principles, advantages, disadvantages and problems.
-Coating - in detail.
-Packaging: materials, labeling etc. Types of containers (e.g. Tamper-proof containers)
-In process controls, Product specification, documentation.
-Compartmental modeling. (From Bramhankar)
-Bioavailability, bioequivalence studies. Methods of improvement of oral bioavailability.
-Evaluation of formulation, principles and methods of release control in oral formulations.


Pharmaceutical analysis:

-Stability testing of pharmaceuticals, various stability tests, kinetic studies, shelf life determination, thermal stability, formulation stability.
-Various analytical techniques
-Tests: physical and chemical tests, limit tests, microbiological tests, biological tests, disintegration and dissolution tests.
-Spectroscopic methods; UV, NMR, IR, MS, FT-IR, FT-NMR, ATR (Attenuated Total Reflectance), FT-Raman- basics and applications.
-Thermal techniques: DSC, DTA, TGA, etc.
-Particle sizing: law of diffraction.
-Electrophoresis: capillary electrophoresis.
-Chromatography- detailed.
-QA and QC: GLP, TQM, ISO system.
-Preformulation, cyclodextrin inclusion compounds
-Solubility: pH, pka, surfactant HLB values, Rheology.
-Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity, surface area flow properties.
-Dosage forms, Stages of dosage form development
-Osmolality, osmolarity, osmotic pressure, conductivity, Preservatives, Media for bioassay.

Biotechnology:, Pharmaceutical technology biotechnology

-Genetic Engg: Gene expression, mutation, replication, transcription, translation, recombination, bacteriophages.
-Cloning: methods, isolation of nucleic acids, enzymes in cloning (restriction endonucleases, DNA ligase, DNA gyrase, polymerases etc...), functions of these enzymes, Pallindromes.
-Fermentation: fermenters, fermentation process, its regulation, conditions, bioprocessors, various enzymes in fermentation technology. Fermentation of Antibiotics, vitamins, amino acids, hydroxy acids such as lactic acid etc. Chemical engg. aspects realated to fermentation
-Gene therapy: methods and applications.
-Monoclonal antibodies, insulin, interferons, enkephalins, angiotensin analogues and other peptides.


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