#1
June 11th, 2016, 02:39 PM
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NIPER Important Notes
Hello sir I am here as I want to get the Important Notes related to NIPER JEE exam as I have to start my preparation so will you please provide me the Notes???
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#2
June 11th, 2016, 04:25 PM
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Re: NIPER Important Notes
As you want Important Notes related to NIPER JEE exam but the notes are not available so below I am providing you syllabus of this Exam Medicinal chemistry -Medicinal chemistry and Bulk Drugs (Pharmaceutical Technology) -IUPAC nomenclature, R and S nomenclature, E and Z isomerism, atropiisomerism, Conformations -Hybridization, aromaticity, Huckel’s rule reaction mechanisms- Electrophilic, Nucleophilic, SN1, SN2, SNi, Elimination E1 E2 etc. -Ester hydrolysis, Aac1 Aac2……all eight mechanisms (Jerry march) Markovnikoves rule, Bredts rule, Stereoselectivity, stereospecificity, regioselectivity, chemoselectivity, chirality, stereochemistry, conformations, rearrangements, acids and bases. -Imine-enamine Tautomerism, keto-enol tautomerism, pericyclic reactions, racemic mixture, resolution methods. -Amino acids proteins, various methods for amino acid detection, Ninhydrin test, peptide sequencing, structures of amino acids, essential and nonessential amino acids, -Introduction to thermal methods of analysis like, TGA, DSC, DTA etc. -Carbohydrates classification, osazone test, mutarotation, etc, -Various Heterocycles, Heterocycle synthesis, reactions. -Introduction to Redox reactions. -Spectroscopy: (basics specially): Very very IMP topic. NMR, and C-NMR ranges from Morrison & Boyd or Pavia Mass -Basic concepts about various peaks M+1, molecular ion, base peak etc. (Silverstein) IR - Frequencies of various groups specially carbonyls. UV -Chromatography: Details of every chromatographic method. -Reaction kinetics, first second third and pseudo first order reactions, radio labeling for determination of mechanism. -Common condensation reactions like Aldol, Claisen Perkin, Dickmann, Darzen etc. -Other reactions like Cannizarro’s reaction, Prins reaction, especially reactions of carbonyl compounds. Natural Products: -In natural products more stress should be given on phytochemistry part rather than biological aspects. -Methods of extraction, isolation and characterization of natural products. Various separation techniques used for isolation of natural products. -Biosynthetic pathways. -Primary metabolites, their examples. -Secondary metabolites, various classes of secondary metabolites (e.g. Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, anthocyanidines etc.). Here most imp. Part is chemistry of these classes. -Important therapeutic classes: antidiabetics, hepatoprotectives, immmunomodulators, neutraceuticals, natural products for gynecological disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc. -Dietary antioxidants, Marine natural products, Plant growth regulators. -Spectroscopy: Basic concepts of UV, NMR, IR and Mass spectroscopy. Give more stress on IR and NMR. -Stereochemistry: Basic concepts. -Fischer, sawhorse and newmon projection formulaes. -Biological sources of important classes of natural products. (Selected ones only) -Standardization of natural products. -What is difference between natural products and pharmacognosy? Pharmacology and toxicology: -Pharmacokinetics, pharmacodynamics, pharmacological effect, desired, undesired, toxic, adverse effects. -Bioavailability, bioequivalence, various factors of ADME. (From Bramhankar) -Drug metabolism: various pathways and other details. -Drug interactions, agonist, antagonist, partial agonist, protein binding, drug distribution, distribution volume, excretion pathways etc. -Pharmacological screening: general principles, various screening models, screening methodologies (in vitro and in vivo tests). -Mechanism of drug action, drug-receptor interaction. -Various adrenergic, cholinergic and other receptors -Detailed study of CNS pharmacology -Study of basis of threshold areas of work in NIPER in pharmacology dept. mentioned in brochure. -Diseases: study of the pharmacology of the diseases and drugs used with mode of action especially of diabetes, malaria, leishmaniasis, TB, hypertension, myocardial ischemia, inflammation, and immunomodualtion. -Chemotherapy and pathophysiology- knowledge of antibiotics, their mode of action and the microorganisms responsible for various common diseases. -Bioassay methods, various requirements. Brief knowledge of the statistical tests. Pharmaceutics and formulation (Pharmaceuticl Technology) -Drug delivery systems (DDS): NDDS models, osmotic pumps, various release patterns eg. Controlled release, delayed release. Sustained release etc., order of release. Oral controlled DDS, factors affecting controlled release. -Carriers in DDS: polymers and their classification, types, carbohydrates, surfactants, proteins, lipids, prodrugs etc. -Transdermal drug delivery systems (TDDS): principles, absorption enhancers, evaluation of TDDS. -Parenterals: requirements, advantages, disadvantages, release pattern, route of drug delivery. -Drug targeting: microspheres, nano particles, liposomes, monoclonal antibodies, etc. -Preformulation detailed. -Complexation, solubilization, polymerization, viscosity measurements. -Dosage form development- stages, implications of dosage form. -Additives of formulation, types, examples, advantages, disadvantages, drug excipient interaction, incompatibility, various types of incompatibilities. -Dosage forms: solid (tablets, capsules, pills etc), liquid (emulsion, suspension etc), sterile (injectables), aerosols. Principles, advantages, disadvantages and problems. -Coating - in detail. -Packaging: materials, labeling etc. Types of containers (e.g. Tamper-proof containers) -In process controls, Product specification, documentation. -Compartmental modeling. (From Bramhankar) -Bioavailability, bioequivalence studies. Methods of improvement of oral bioavailability. -Evaluation of formulation, principles and methods of release control in oral formulations. Pharmaceutical analysis: -Stability testing of pharmaceuticals, various stability tests, kinetic studies, shelf life determination, thermal stability, formulation stability. -Various analytical techniques -Tests: physical and chemical tests, limit tests, microbiological tests, biological tests, disintegration and dissolution tests. -Spectroscopic methods; UV, NMR, IR, MS, FT-IR, FT-NMR, ATR (Attenuated Total Reflectance), FT-Raman- basics and applications. -Thermal techniques: DSC, DTA, TGA, etc. -Particle sizing: law of diffraction. -Electrophoresis: capillary electrophoresis. -Chromatography- detailed. -QA and QC: GLP, TQM, ISO system. -Preformulation, cyclodextrin inclusion compounds -Solubility: pH, pka, surfactant HLB values, Rheology. -Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity, surface area flow properties. -Dosage forms, Stages of dosage form development -Osmolality, osmolarity, osmotic pressure, conductivity, Preservatives, Media for bioassay. Biotechnology:, Pharmaceutical technology biotechnology -Genetic Engg: Gene expression, mutation, replication, transcription, translation, recombination, bacteriophages. -Cloning: methods, isolation of nucleic acids, enzymes in cloning (restriction endonucleases, DNA ligase, DNA gyrase, polymerases etc...), functions of these enzymes, Pallindromes. -Fermentation: fermenters, fermentation process, its regulation, conditions, bioprocessors, various enzymes in fermentation technology. Fermentation of Antibiotics, vitamins, amino acids, hydroxy acids such as lactic acid etc. Chemical engg. aspects realated to fermentation -Gene therapy: methods and applications. -Monoclonal antibodies, insulin, interferons, enkephalins, angiotensin analogues and other peptides. |