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  #1  
April 22nd, 2015, 08:22 AM
Unregistered
Guest User
 
PTU Risks

I missed the dose of the Propylthiouracil (PTU). I am worried about my health now. What are the risks of the Propylthiouracil (PTU) If I missed the two dose? Am I going to die really soon? Is the risk of missing the does affect not my health
  #2  
February 18th, 2017, 01:08 PM
Unregistered
Guest User
 
Re: PTU Risks

Hello Sir, I want to know the risks of PTU (propylthiouracil) so can you tell me? Also tell me the signs of it?
  #3  
February 18th, 2017, 01:09 PM
Super Moderator
 
Join Date: Mar 2012
Re: PTU Risks

There are two main drugs used to treat Graves’ Disease medically – MMI (methimazole or it’s nearly identical relative carbimazole) and PTU (propylthiouracil).

As with all drugs, there are risks and side effects.

The listed risks (liver failure, loss of white blood cells) are terrifying, and yet, very few people ever experience these.

Currently in the US, about 25% of Graves’ patients are on PTU. Doctors prescribe PTU rather than MMI for several reasons.

PTU is considered better for pregnant women, especially during the first trimester, as MMI can sometimes cause birth defects.

Some people have an allergic reaction or other mild side effects from MMI and so take PTU instead.

Because of this, the general trend is to prescribe MMI first, and if that doesn’t work for some reason (pregnancy or adverse reaction), then switch to PTU.

MMI is also considered “better” than PTU in that in is more effective when people are severely hyperthyroid, people adhere to it better, and it causes less toxicity, especially at low doses.

There are approximately 600,000 60,000 new cases of Graves’ diagnosed in the US each year.

Of these, 25% get put on PTU for one of the above reasons, so there are 15,000 people who start taking PTU each year. Of these people, approximately 1 in 1000, or 15 people total, develop severe liver damage, and 1 or 2 die.

Various organizations keep different sorts of records on PTU-related liver failure.

For instance, there are 42 cases reported in the scientific literature since 1947, while the FDA knows of 47 cases.

UNOS (the organ transplant association) reported 23 liver transplants over a 17-year period related to PTU, but none related to MMI.

The FDA-AERS database lists 34 cases of liver failure in the last 20 years.

Because liver toxicity happens so rapidly, routine monitoring of liver values is not helpful. Monitoring does not reduce the risk of liver injury because of the unpredictable nature of the drug reaction.

Signs of liver failure include:

jaundice (yellowish skin or eyes)
fatigue or malaise (tiredness)
nausea
anorexia (no appetite)
pharyngitis (sore throat)

If you have any of these signs, stop taking PTU and go get your liver enzymes checked immediately.


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