hii sir, I am preparing for the GPAT Entrance Examination will you please provide me the previous year question paper of the GPAT Examination so that I may have a general idea about the Examination ?

As you asking for the previous year question paper of the GPAT Examination the questions are as follow :

The study of identification and comparative evaluation of a new drug with existing
drug is known as
a. Pharmacogenomics b. Pharmcometrics
c. Pharmacoeconomics d. Pharmacoepidemiology

2. Pharmacoepidemiology is emerging branch of pharmacy. Pick the correct
options
P. It is an important topic for regulatory authorities for issuing licence
Q. It deals with identification and comparative evaluation of drugs
R. It deals with study of drug effects over a group of population
S. Licensing authorities do not require details of pharmacy oepidemology
a. P, Q b. P,R c. R,S d. Q,R

3. Therapeutic index is determined in which phase of clinical trials
a. Phase-I b. Phase-III
c. Phase-II d. Phase-IV

4. Pick the wrong option regarding idiosyncratic reaction.
a. They are not predictable and uncommon
b. Do not depend on the dose
c. It may be due to immunological and genetic cause
d. Withdrawl of drug is not required

5. Therapeutic index is a ratio of toxic dose to effective dose. Pick correct options
P. Larger the TI, safer the drug
Q. Smaller the TI, toxic the drug
R. Larger the TI, toxic the drug
S. Smaller the TI, safer the drug
a. P,Q b. Q,R c. R,S d. S, P

6. Type –A adverse drug reactions are characterized by which of the following.
a. Idiosyncratic reaction b. A function of patient’s susceptibility
c. Caused by drug-drug interactions d. All the above

7. Withdrawl symptoms are elicited by
a. Clonidine b. Benzodiazepines
c. Tricyclic anti depressants d. All the above

8. Parkinsonism is produced by phenothiazines and antipsychotic drugs. It is known as
a. Iatrogenic b. Idopatic
c. Teratogenic d. Carcinogenic

9. Teratogenic effect of phenytoin is
a. Hypoplastic phalanges b. Cleft lip
c. Both a & b d. None of the above

10. Hydrochlorthiazides and triamterene produce which type of antagonism
a. Competitive antagonism
b. Non-competitive antagonism
c. Physiological antagonism
d. None of the above

11. Sublingual route of administration has the following properties except
a. Rapid onset of action
b. Devoid of first pass metabolism
c. Reduce toxic and adverse reactions
d. High molecular weight compounds can be given

12. The term isobaro is an important factor for
a. Intrathecal injections b. Intravenous injections
c. Subcutaneous injections d. All the above

13. To diagnose “Heart block”, angiography is performed, the route selected for injecting radiolabelled dye is
a. I.V b. S.C
c. Intra-arterial d. Intra-articular

14. Phlebitis is an important disadvantage of which route of administration
a. SC b. Oral
c. IM d. IV

15. Allosteric antagonism is a mechanism of action of which of the following drug
a. Adrenaline b. Diazepam
c. Atenolol d. None of the above

16. Na+ / K+ ATPase pump is an example of which transport.
a. Symport b. Antiport
c. Both a and b d. None of the above

17. Creatinine clearance is measured by
a. Renal excretion rate b. Drug metabolism rate
c. Active renal secretion d. Glomerular filtration rate


18. The intensity of the pharmacological action of a drug mostly depends on
a. Concentration of drug at the receptor site
b. Minimum toxic concentration of the drug
c. Minimum effective concentration of the drug
d. Elimination half life of the drug

19. Earliest evidence that a drug is stored in tissue is
a. Increase in plasma protein binding
b. Large apparent volume of distribution
c. Decrease in the amount of drug excreted by urine
d. Decrease in the number of side effects produced by drug


20. Olsalazine is
a. Inactive drug biotransformed to an active drug
b. Active drug biotransformed to inactive drug
c. Invivo enzymatic transformation into non toxic metabolite
d. Invivo enzymatic transformation into drug with reduced side effects

21. The receptor, which produces faster action is
a. Ligand-gated ion channel
b. G-protein coupled receptor
c. Kinase-linked receptor
d. Nuclear receptor

22. Name the drug, which inhibits phosphodiesterases
a. Caffeine b. Sildenafil
c. Indomethacine d. All the above

23. Name the enzyme, which converts PIP2 to IP3 and DG
a. Phospholipase-C b. Phospholipase-A
c. Phosphodiesterase d. Carbonic anhydrase

24. Among the following, which one is a secondary messenger
a. c-AMP b. IP3
c. DAG d. All the above

25. Nicotinic receptor is an example of
a. Ligand-gated ion channel
b. G-protein coupled receptor
c. Kinase-linked receptor
d. Nuclear receptor

26. An agent used in prinzmetal angina and has spasmolytic activity is
a. Nitroglycerine
b. Nifedipine
c. Timolol
d. Iso-sorbide mononitrate

27. The type of tolerance shown by nitrates is
a. Tissue tolerance
b. Cross tolerance
c. Both a and b
d. None of the above

28. By which of the following, nitroglycerine’s tolerance can be overcome?
a. Using high dose of drug
b. Discontinuing of drugs for 2-3 weeks
c. Avoiding the drug at night time
d. Using drug in the form of SR tablet and transdermal preparation