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As you want to download JIPMER Journal of Cancer Volume 1, so here I am providing link to download complete JIPMER Journal of Cancer Volume 1:

JIPMER Journal of Cancer Volume 1
It is an Official publication of Pondicherry Regional Cancer Society.

This is a peer reviewed journal and acts as a medium for communicating the latest research in the field of oncology and cancer therapeutics.

Editorial
Dr. K.S. Reddy

Review Articles
Risk of cancer in women on hormone replacement therapy – an overview
P. Reddi Rani, K.S. Reddy

Trastuzumab in the treatment of breast cancer: current status
Beela Sarah Mathew

Letter to the Editor
Local and distant recurrence occuring after 20 years in carcinoma breast
Ashutosh Mukherji, A.K. Rathi, Kishore Singh
Images
Primary intra-osseous hemangioma of the skull base – CT and MR imaging features
S.M. Carthikeyan,Venkatesh Madhugiri, K.S. Reddy, S. Gangothri,
N.V. Vinin, K. Sudhakar, Shyama Gopalakrishnan

Risk of cancer in women on hormone replacement therapy – an overview
Keywords: Hormone replacement therapy, cancer
HRT and risk of breast cancer in postmenopausal women With ET use alone, the average risk of invasive breast cancer was 0.81 in four randomized trials involving 12,643 women.

With E + P therapy the average breast cancer risk was 1.24 in randomized trials involving
19,756 women.

The absolute effect of E + P therapy in WHI and heart and oestrogen and progestin replacement study trials added 8 and 17 cases per 10,000 women per year respectively, to natural risk.

Data from Million women study showed the increased risk to current users of ET, EPT and
Tibolone as 1.30, 2.00 and 1.45 respectively but the magnitude of the associated risk was
substantially greater for E + P therapy than the other types of HRT (P<0.0001)

Six epidemiological studies including MWS showed the average relative risk with
sequential and continuous progestin regimens were 1.85 and 1.94 respectively, a difference
that was not significant.
References 1. Writing group for the Women’s Health initiative investigators. Risks and benefits of oestrogen plus progestin in healthy postmenopausal women. Principal results from the Women’s Health initiative randomized Controlled trial JAMA. 2002; 288(3):321-333.

2. The Women’s Health Initiative screening committee. Effects of conjugated equine oestrogen in postmenopausal women with hysterectomy: the Women’s health Initiative randomized Controlled trial JAMA. 2004; 291 (14): 1701-1712.

3. Million woman’s study collaborators: Breast cancer and hormone replacement therapy in the Million women Study. Lancet. 2003; 302: 419-427.

4. The North American Menopause Society: High lights of a new position statement on hormone therapy.Contemporary Obst Gynae. 2007; 5:1- 4.

5. Stefanick ML, Anderson GL, Margolis KL, Hendrix SL. Effects of conjugated equine oestrogens on breast cancer and mammography screening in post menopausal women with hysterectomy. JAMA. 2006; 295:1647-1657

6. Hulley S, Furberg C, Barrett-Connor E, Cauley J. Non cardiovascular disease outcomes during 6-8 of hormone therapy. Heart and oestrogen / progestin replacement study follow up (HER SII) JAMA. 2002; 288:58-66.

7. Collins JA, Blake JM, Crosignani PG. Breast cancer risk with post menopausal hormone treatment. Hum Reprod Update. 2005; 11:545-560.

8. Anderson GL, Chlebowski RT, Aragaki AK, et al.Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women’s Health Initiative randomizes placebo-controlled trial. Lancet
Oncol. 2012; 13:476-486.

9. Chlebowski RT, Anderson GL. Changing Concepts: Menopausal Hormone Therapy and Breast Cancer. J Natl Cancer Inst. 2012; 104:517-527.

Attached Files

JIPMER Journal of Cancer Volume 1.pdf (7.71 MB, 106 views)