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NIPER JEE (MS and Ph.D.) Syllabus :
Departments:

Medicinal chemistry
Natural products
Pharmacology and toxicology
Pharmaceutics
Pharmaceutical analysis
Pharmaceutical technology (Bulk drugs) (chemistry)
Pharmaceutical technology (Formulation) (Pharmaceutics)
Pharmaceutical technology Biotechnology (PTBT)
Biotechnology
Practice of pharmacy.
Pharmacoinformatics
Toxicology.

Syllabus :

Natural Products:

In natural products more stress should be given on phytochemistry part
rather than biological aspects.

Methods of extraction, isolation and characterization of natural products.
Various separation techniques used for isolation of natural products.

Biosynthetic pathways.

Primary metabolites, their examples.

Secondary metabolites, various classes of secondary metabolites (e.g.
Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids,
coumarins, anthocyanidines etc.). Here most imp. Part is chemistry of these
classes.

Important therapeutic classes: antidiabetics, hepatoprotectives,
immmunomodulators, neutraceuticals, natural products for gynecological
disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc.

Dietary antioxidants, Marine natural products, Plant growth regulators.

Spectroscopy: Basic concepts of UV, NMR, IR and Mass spectroscopy. Give
more stress on IR and NMR.

Stereochemistry: Basic concepts.

Fischer, sawhorse and newmon projection formulaes.

Biological sources of important classes of natural products. (Selected ones
only)

Standardization of natural products.

What is difference between natural products and pharmacognosy?



Pharmacology and toxicology:

Pharmacokinetics, pharmacodynamics, pharmacological effect, desired, undesired, toxic, adverse effects.

Bioavailability, bioequivalence, various factors of ADME. (From Bramhankar)

Drug metabolism: various pathways and other details.

Drug interactions, agonist, antagonist, partial agonist, protein binding, drug
distribution, distribution volume, excretion pathways etc.

Pharmacological screening: general principles, various screening models,
screening methodologies (in vitro and in vivo tests).

Mechanism of drug action, drug-receptor interaction.

Various adrenergic, cholinergic and other receptors

Detailed study of CNS pharmacology

Study of basis of threshold areas of work in NIPER in pharmacology dept.
mentioned in brochure.

Diseases: study of the pharmacology of the diseases and drugs used with
mode of action especially of diabetes, malaria, leishmaniasis, TB,
hypertension, myocardial ischemia, inflammation, and immunomodualtion.

Chemotherapy and pathophysiology- knowledge of antibiotics, their mode of
action and the microorganisms responsible for various common diseases.

Bioassay methods, various requirements. Brief knowledge of the statistical
tests.


Pharmaceutics and formulation (Pharmaceuticl Technology)
Drug delivery systems (DDS): NDDS models, osmotic pumps, various
release patterns eg. Controlled release, delayed release. Sustained release
etc., order of release. Oral controlled DDS, factors affecting controlled
release.

Carriers in DDS: polymers and their classification, types, carbohydrates,
surfactants, proteins, lipids, prodrugs etc.

Transdermal drug delivery systems (TDDS): principles, absorption
enhancers, evaluation of TDDS.

Parenterals: requirements, advantages, disadvantages, release pattern,
route of drug delivery.

Drug targeting: microspheres, nano particles, liposomes, monoclonal
antibodies, etc.

Preformulation detailed.

Complexation, solubilization, polymerization, viscosity measurements.

Dosage form development- stages, implications of dosage form.

Additives of formulation, types, examples, advantages, disadvantages, drug
excipient interaction, incompatibility, various types of incompatibilities.

Dosage forms: solid (tablets, capsules, pills etc), liquid (emulsion,
suspension etc), sterile (injectables), aerosols. Principles, advantages,
disadvantages and problems.

Coating - in detail.

Packaging: materials, labeling etc. Types of containers (e.g. Tamper-proof
containers)

In process controls, Product specification, documentation.

Compartmental modeling. (From Bramhankar)

Bioavailability, bioequivalence studies. Methods of improvement of oral
bioavailability.

Evaluation of formulation, principles and methods of release control in oral
formulations.



Pharmaceutical analysis:

Stability testing of pharmaceuticals, various stability tests, kinetic studies,
shelf life determination, thermal stability, formulation stability.

Various analytical techniques

Tests: physical and chemical tests, limit tests, microbiological tests,
biological tests, disintegration and dissolution tests.

Spectroscopic methods; UV, NMR, IR, MS, FT-IR, FT-NMR, ATR (Attenuated
Total Reflectance), FT-Raman- basics and applications.

Thermal techniques: DSC, DTA, TGA, etc.

Particle sizing: law of diffraction.

Electrophoresis: capillary electrophoresis.

Chromatography- detailed.

QA and QC: GLP, TQM, ISO system.

Preformulation, cyclodextrin inclusion compounds

Solubility: pH, pka, surfactant HLB values, Rheology.

Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity,
surface area flow properties.

Dosage forms, Stages of dosage form development

Osmolality, osmolarity, osmotic pressure, conductivity, Preservatives, Media
for bioassay.


Biotechnology:, Pharmaceutical technology biotechnology
Genetic Engg: Gene expression, mutation, replication, transcription,
translation, recombination, bacteriophages.

Cloning: methods, isolation of nucleic acids, enzymes in cloning (restriction
endonucleases, DNA ligase, DNA gyrase, polymerases etc...), functions of
these enzymes, Pallindromes.

Fermentation: fermenters, fermentation process, its regulation, conditions,
bioprocessors, various enzymes in fermentation technology. Fermentation of
Antibiotics, vitamins, amino acids, hydroxy acids such as lactic acid etc.
Chemical engg. aspects realated to fermentation

Gene therapy: methods and applications.

Monoclonal antibodies, insulin, interferons, enkephalins, angiotensin
analogues and other peptides.



Practice of Pharmacy:

The best part for the preparation for this best reference for this would be
Remington’s Pharmaceutical Sciences. This branch is quite new here, so till
dates students of branch used to do case study of prescriptions in Fortis
hospital, PGI Chandigarh and govt. college chd... This is much like
pharmacology and drug-drug interactions and different interactions are
emphasized. Diabetes, heart diseases are main area of study……….

Pharmacoinformatics:

Terminologies related with new emerging informatics e.g. proteomics,
genomics, QSAR (2D, 3D, regression, correlation).


Address:
National Institute Of Pharmaceutical Education And Research - NIPER Ahmedabad
C/o.B. V. Patel PERD Centre
Sarkhej - Gandhinagar Hwy
Someshwar Park-3, Thaltej
Ahmedabad, Gujarat 380054