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February 7th, 2013, 02:14 PM
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TIFR Biology Question Papers

Will you please provide me the Tata Institute of Fundamental Research Biology Question Papers?

You are looking for the Tata Institute of Fundamental Research Biology Question Paper, here I am uploading a file form where you can download the Tata Institute of Fundamental Research Biology Question Paper, some of the questions are as follows:

1. Fruitflies have a red eye colour that is determined by the gene RED. Allele R
gives a red eye and allele r gives a white eye. R is dominant over r. A single
red eye parent and a single white eye parent were mated. Only 50% of the
resulting progeny had red eyes. With respect to the RED gene, which of the
following best describes the genotype of the red eyed parent?
a. rr
b. Rr
c. RR
d. Any of the above

2. The pI of a protein is 8.3. To carry out ion-exchange chromatography of this
protein at pH=7.0, the following should be used to ensure binding and
fractionation:
a. Cation exchanger resin
b. Anion exchanger resin
c. Reactive ion exchanger resin
d. Polyanion exchanger resin

3. Genetic sequence data were used to construct the following evolutionary tree
relating Mus muculus, Rattus rattus and Homo sapiens.
Which of the following is NOT true?
a. Mice are descended from the last common ancestor of humans and rats.
b. Rats are descended from the last common ancestor of humans and mice
c. Humans are descended from the last common ancestor of rats and mice
d. Humans, mice, and rats have a common ancestor

4. A significant proportion of students at TIFR seem to have descended from
Chengis Khan. This information was inferred from:
a. Mitochondrial DNA
b. Single Nucleotide Polymorphisms
c. Y chromosome analysis
d. Ancient DNA

5. The recognition sequence for the restriction endonuclease AstWI is GRCGYC
where R is any Purine and Y is any Pyrimidine base. In a truly random DNA
sequence what will be the average distance (measured in base pairs) between
successive AstWI cut sites?
a. 1024
b. 512
c. 4096
d. 24

6. Jitesh carried out a steady-state kinetics experiment for an enzyme degradase
with and without molecule X as part of the reaction mixture. The reactions
were carried out for 5 minutes and he got the following results:

11. Champa is trying to characterize a gene s4, which has been previously
implicated in early development in mice. Her attempts to characterize the
phenotype failed because embryos from crossed homozygous mutant parents
did not survive. However, she was able to get some viable homozygous
embryos when heterozygous parents were crossed. Which of the following
can explain this observation?
a. s4 is a critical gene for early development and is maternally required*
b. s4 is a critical gene for early development and is an imprinted gene
c. Both a and b
d. None of the above

12. Alzheimers’ protein-A multimerizes at pH 2 to form aggregates which
leads to Alzheimers’ disease. In the brain the pH is always neutral ~7. So
what leads to aggregation of A that induces Alzheimers’ in people greater
than 60 years of age?
a. Older brains are more acidic.
b. At pH 7, there will be very fast kinetic equilibrium between oligomers
and monomers which can change with age to induce aggregation
c. At pH 7, the reaction does proceed to oligomerization but the rate is so
low that it takes 60 years to form aggregates
d. Aggregates form during intermittent drops in pH throughout your life.

13. Mutations in two genes x and y in a diploid organism when present
togather cause lethality. Which of the following may be inferred about the
nature of the gene product?
a. The product of the genes function as an oligomer
b. The two genes fall in the same complementation group
c. None of above
d. The product is a homo-oligomer

14. A gene is transcribed at the maximum rate of k per second, and codes
for a transcription factor (TF). This transcription factor inhibits the
transcription of its own gene, and this is the only way this gene and TF are
regulated. Which of the following graphs is most likely to describe how the
steady-state concentration of the TF depends on the value of k?
a. A and C
b. C
c. B
d. D

For the detailed question paper, here is attachment:
Attached Files
File Type: pdf TIFR Biology Question Paper.pdf (484.6 KB, 76 views)

Last edited by Neelurk; March 12th, 2020 at 02:14 PM.
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