Mechanical forces play a essential role in ubiquitous phenomena such as cell-adhesion, tissue organization, and muscle function in multi-cellular organisms. Cell-adhesion is also crucial in wound healing, protecting us from microorganisms, and maintaining immunity.

Publications

1. Koti AS, Wiita AP, Dougan L, Uggerud E, Fernandez JM (2008) Single-Molecule force spectroscopy measurements of bond elongation during a bimolecular reaction. Journal of the American Chemical Society 130: 6479

2. Koti AS, Wiita AP, Huang HH, Fernandez JM (2008) A Single-Molecule Assay to Directly Identify Solvent Accessible Disulfide Bonds and Probe Their Effect on Protein Folding. Journal of the American Chemical Society 130: 436

3. Koti AS, Brujic J, Huang HH, Wiita AP, Li L, Lu H, Walther K, Carrion-Vazquez M, Li H, Fernandez JM (2007) Contour length and refolding rate of a small protein controlled by engineered disulfide bonds.Biophysics Journal 92: 225

4. Wiita AP, Koti AS, Huang HH, Fernandez JM (2006) Force-dependent chemical kinetics of disulfide bond reduction observed with single molecule techniques. Proceedings of National Academy of Sciences USA 103: 7222

5. Koti AS, Li L, Badilla CL, Fernandez JM (2005) Ligand binding modulates the mechanical stability of dihydrofolate reductase (DHFR). Biophysical Journal 89: 3337

Departmental and TIFR Seminars and Colloquia
• DBS Seminar Series
• TIFR ASET Colloquium
• TIFR Wednesday Colloquium


Past activities

39th Mahabaleshwar Seminar in Modern Biology: Recent Advances in Zebrafish Genetics and Development (21-24 March 2015)
ADULT NEUROGENESIS: From Stem Cells to Therapies (ANSCT2014) (6-8 February 2014)
XXXVIII Mahabaleshwar Seminar: Mtiochondria, Metabolism and Energetics (27-30 January 2014)
InSDB conference 2013 (2-4 December 2013)
DBS Annual Talks 2013 (6-8 August 2013)
Genes, Circuits and the Development of Behaviour (GCDB-2013) (March 2013)
Axonal Transport and Neurodegenerative Disorder (ATND) - XXXVI Mahabaleshwar Seminar on Modern Biology: Molecular Motors, Transport and Trafficking (M2T2) (January 2013)
DBS@50 (August 2012)
15th Transcription Meeting (22-24 January 2012)
ISDN 2012: 19th Biennial Meeting of the International Society for Developmental Neuroscience (11-14 January 2012)
International Conference on Yeast Biology (10-13 December 2011)

Contact Details:

TIFR
Room FTNMR2 (Department of Chemical Sciences)
Tel: +91 22 2278 2790
koti @ tifr.res.in