#1
February 7th, 2017, 05:17 PM
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Study Material for GPAT and NIPER
I and my sister have applied for GPAT and NIPER JEE Entrance Exam respectively. We need study material of these exams to start preparation. So someone is here who can provide link to download study material for GPAT and NIPER JEE Exams?
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#2
February 7th, 2017, 05:35 PM
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Re: Study Material for GPAT and NIPER
As you are looking for study material for GPAT and NIPER JEE Entrance Exams, so here I am providing syllabus of both exams for your reference: NIPER JEE ENTRANCE EXAM SYLLABUS SPECIALIZATION SUBJECTS Medicinal chemistry and Bulk Drugs (Pharmaceutical Technology) IUPAC nomenclature, R and S nomenclature, E and Z isomerism, atropiisomerism, Conformations Hybridization, aromaticity, Huckel’s rule reaction mechanisms- Electrophilic, Nucleophilic, SN1, SN2, SNi, Elimination E1 E2 etc. Ester hydrolysis, Aac1 Aac2……all eight mechanisms (Jerry march) Markovnikoves rule, Bredts rule, Stereoselectivity, stereospecificity, regioselectivity, chemoselectivity, chirality, stereochemistry, conformations, rearrangements, acids and bases. Imine-enamine Tautomerism, keto-enol tautomerism, pericyclic reactions, racemic mixture, resolution methods. Amino acids proteins, various methods for amino acid detection, Ninhydrin test, peptide sequencing, structures of amino acids, essential and nonessential amino acids, Introduction to thermal methods of analysis like, TGA, DSC, DTA etc. Carbohydrates classification, osazone test, mutarotation, etc, Various Heterocycles, Heterocycle synthesis, reactions. Introduction to Redox reactions. Spectroscopy: (basics specially): Very very IMP topic. NMR, and C-NMR ranges from Morrison & Boyd or Pavia Mass -Basic concepts about various peaks M+1, molecular ion, base peak etc. (Silverstein) IR - Frequencies of various groups specially carbonyls. UV Chromatography: Details of every chromatographic method. Reaction kinetics, first second third and pseudo first order reactions, radio labeling for determination of mechanism. Common condensation reactions like Aldol, Claisen Perkin, Dickmann, Darzen etc. Other reactions like Cannizarro’s reaction, Prins reaction, especially reactions of carbonyl compounds. NATURAL PRODUCTS: In natural products more stress should be given on phytochemistry part rather than biological aspects. Methods of extraction, isolation and characterization of natural products. Various separation techniques used for isolation of natural products. Biosynthetic pathways. Primary metabolites, their examples. Secondary metabolites, various classes of secondary metabolites (e.g. Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, anthocyanidines etc.). Here most imp. Part is chemistry of these classes. Important therapeutic classes: antidiabetics, hepatoprotectives, immmunomodulators, neutraceuticals, natural products for gynecological disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc. Dietary antioxidants, Marine natural products, Plant growth regulators. Spectroscopy: Basic concepts of UV, NMR, IR and Mass spectroscopy. Give more stress on IR and NMR. Stereochemistry: Basic concepts. Fischer, sawhorse and newmon projection formulaes. Biological sources of important classes of natural products. (Selected ones only) Standardization of natural products. What is difference between natural products and pharmacognosy? PHARMACOLOGY AND TOXICOLOGY: Pharmacokinetics, pharmacodynamics, pharmacological effect, desired, undesired, toxic, adverse effects. Bioavailability, bioequivalence, various factors of ADME. (From Bramhankar) Drug metabolism: various pathways and other details. Drug interactions, agonist, antagonist, partial agonist, protein binding, drug distribution, distribution volume, excretion pathways etc. Pharmacological screening: general principles, various screening models, screening methodologies (in vitro and in vivo tests). Mechanism of drug action, drug-receptor interaction. Various adrenergic, cholinergic and other receptors Detailed study of CNS pharmacology Study of basis of threshold areas of work in NIPER in pharmacology dept. mentioned in brochure. Diseases: study of the pharmacology of the diseases and drugs used with mode of action especially of diabetes, malaria, leishmaniasis, TB, hypertension, myocardial ischemia, inflammation, and immunomodualtion. Chemotherapy and pathophysiology- knowledge of antibiotics, their mode of action and the microorganisms responsible for various common diseases. Bioassay methods, various requirements. Brief knowledge of the statistical tests. PHARMACEUTICS AND FORMULATION (PHARMACEUTICL TECHNOLOGY) Drug delivery systems (DDS): NDDS models, osmotic pumps, various release patterns eg. Controlled release, delayed release. Sustained release etc., order of release. Oral controlled DDS, factors affecting controlled release. Carriers in DDS: polymers and their classification, types, carbohydrates, surfactants, proteins, lipids, prodrugs etc. Transdermal drug delivery systems (TDDS): principles, absorption enhancers, evaluation of TDDS. Parenterals: requirements, advantages, disadvantages, release pattern, route of drug delivery. Drug targeting: microspheres, nano particles, liposomes, monoclonal antibodies, etc. Preformulation detailed. Complexation, solubilization, polymerization, viscosity measurements. Dosage form development- stages, implications of dosage form. Additives of formulation, types, examples, advantages, disadvantages, drug excipient interaction, incompatibility, various types of incompatibilities. Dosage forms: solid (tablets, capsules, pills etc), liquid (emulsion, suspension etc), sterile (injectables), aerosols. Principles, advantages, disadvantages and problems. Coating - in detail. Packaging: materials, labeling etc. Types of containers (e.g. Tamper-proof containers) In process controls, Product specification, documentation. Compartmental modeling. (From Bramhankar) Bioavailability, bioequivalence studies. Methods of improvement of oral bioavailability. Evaluation of formulation, principles and methods of release control in oral formulations. GPAT ENTRANCE EXAM SYLLABUS PHYSICAL CHEMISTRY 1. Composition & physical states of matter Intermolecular forces & their impact on state of the matter. Various physical properties of matter, dipole moment, dielectric constant, Van Der waal's equation & critical phenomenon, liquefaction of gases, aerosols. 2. Colligative Properties The liquid state, vapor pressure, ideal & real solutions. Raoult's law, elevation of boiling point, depression of freezing point, osmotic pressure, determination of molecular weight based on colligative properties. 3. Thermodynamics First, second & third law of thermodynamics. Thermochemical laws, isothermic & adiabetic processes, reversible processes, work of expansion, heat content, enthalpy, heat capacity. Gibb's & Helmoltz equation & chemical potential. 4. Chemical Equillibria. 5. Phase rule One, two, & three component systems along with their applications. Solid- solid, solid - liquid, & liquid-liquid systems. Distillation of binary systems, azeotropic mixtures, steam, vacuum, & fractional distillation. 6. Refractive index Refractive index, specific refractivity, molar refractivity, refractometers. 7. Solutions Solubility, factors affecting solubility, solubility curves. Types of solutions, effect of cosolvancy, pH & other factors on solubility. Solubility of gases in liquids, liquids in liquids, & solids in liquids, critical solution temperature, law of partitioning & its applications. Solute solvent interactions. Expression of concentration of pharmaceutical solutions & calculations. Molarity, molality, mole fraction & percentage expressions. 8. Electrochemistry Properties of electrolyte solutions, electrolysis. Faraday's law of electrolysis, electron transport, electrical cell, single electrode potential, concentration cells, half-cells & half cell potential, types of half cells, sign convention, Nerst equation, salt bridge, electromotive series, standard potential, SHE. Measuring the relative voltage of half cells, Calculation of standard potential. Reference & indicator electrodes. Standard oxidation-reduction potential 9. Ionic equilibrium Theory of conductivity, equivalent conductance, mobility of ions, specific conductance. 10.Kinetics Order of reactions, derivation & internal form of rate laws, molarities of reaction, derivation of rate constants. To download complete syllabus, download the attachment......... |
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